Holy Family Parish was organized on September 4, 1957 as a result of a decision by then Jackson Diocese Bishop Richard Gerow.  The Northeast Jackson area was experiencing a population boom, and while the area was growing, the nearest Catholic Church (St. Richard's) was several miles away.  Father (now Monsignor) Michael Glynn was appointed to lead the new parish which originally consisted of young, White, middle class families.  Many of these families had previously attended the much larger St. Richard's Parish.

The Parish's initial construction, a chapel to seat 375 and two classrooms, was dedicated by Bishop Gerow and Bishop Joseph Brunini in January, 1959.  By 1963, four additional classrooms, a cafeteria, a convent and the rectory were built and dedicated.  This second phase of construction meant that Father Glynn would have a home and the Parish now had its own school.